St Anthony's Primary School was opened in 1968 by the Presentation Sisters to serve the growing number of children in the Parish. During the years, enrolment numbers grew from the original 51 students pupils to the size that it is today with the necessary expansion and modernisation required. The site has grown into a modern contemporary learning space from humble beginnings where students were educated in the old Uki Convent School building.

The Foundation Principal was Sister Margaret Mazza, and she and the other Sisters travelled first from Tumbulgum and then later on from Tweed Heads. The Principals who followed were Sister Agnes Gaghan, Sister Maria Thomas, and all Presentation Sisters who continued to staff the school until 1980. Since then, the school has been under the leadership of a lay principal and staffed by lay teachers.

Paul Hookway was the first lay Principal appointed, and he remained in the position from 1980 until 1992. Robert Lewis replaced Paul in 1993 and held the position until 1999. Michelle Campbell was Principal from 2000 until 2009. Tony Boyle was Acting Principal for the 2010 school year until a new Principal, Lynne Pull, was appointed at the beginning of the 2011 school year.